R&D priorities in biotechnology are essential to take care of post-Kyoto challenges:

R&D priorities in biotechnology are essential to take care of post-Kyoto challenges:

A. Global Warming: The third session of the Conference of the Parties to the United Nations Framework Convention on Climate change, held in Kyoto, Japan, on December 1997, agreed on a protocol which includes each party’s quantitative commitment to reduce its emissions of greenhouse gases, such as carbon dioxide (CO2) by 2010. The protocol specifies that the European Union will commit itself to reducing its greenhouse gas emissions by 8 per cent by 2010 from the level of 1990 (base year), the United States by 7 per cent, and Japan and Canada by 6 per cent. As an essential element in achieving this goal, industry must reduce energy consumption in order to maintain development while helping to meet these targets.

This would include a shift from present petrochemical industry processes, which consume large quantities of energy under conditions of high temperature and pressure, to more energy-efficient biological processes, which use renewable resources such as biomass to produce useful substances under normal temperatures and pressures. For example, future processes will focus more on producing efficiently alternative fuels such as ethanol, which contribute less to global warming and are also likely to produce environmentally benign products, such as biodegradable plastics, which breaks down in natural settings after use.

As a result, biotechnology should become an increasingly valuable tool for developing environmentally friendly products and processes and for preventing the Earth from warming.

B. R&D priorities in biotechnology for promotion of clean industrial products and processes: If biotechnology is to become an increasingly important source of clean industrial products and processes, R&D efforts will need to focus on a number of priority areas. Among those that deserve prompt and focused research in the near future are:

a. Innovative products derived from biological sources that contribute to sustainability;

b. Wider exploration of biological systems (enzymes, micro-organisms, cells, whole organisms);

c. Greater emphasis on the use of bioconsortia, including establishing them and developing production and degradation processes based on them;

d. Novel methodologies for developing biological processes (bio-molecular design, genomics);

e. Innovative biocatalyst technology for use in areas where conventional biocatalysts have not yet been exploited (e.g. the petrochemical industries);

f. Biological recycling processes that convert unused resources to useful substances;

g. Emphasis on engineering, especially large-scale engineering, process intensification, measurement, monitoring and control systems;

h. Greater emphasis on biodiversity and widening the search for novel genes (bioprospecting), a process that will require, in parallel, the construction of infrastructures such as culture collections, comprehensive biological databases, and the development of bioinformatics;

i. Focus on development and application of recombinant technology.

Biotechnology to address many global environmental concerns:

Biotechnology to address many global environmental concerns:

A. Industrial biotechnology has come of age. Improved industrial sustainability through biotechnology addresses many global environmental concerns. Biotechnology has clear environmental advantages and is economically competitive in a growing number of industrial sectors. It enables reductions of material and energy consumption, as well as pollution and waste generation, for the same level of industrial production. Continued technical innovation, including that based upon recombinant DNA technology, is vital for the wider utilisation of biotechnology by industry.

B. With biotechnology, the emphasis is no longer on the removal of pollutants from an already damaged environment, but on the need to reshape industrial process technologies to prevent pollution at the source. Achieving ‘‘clean technology’’ or ‘‘industrial sustainability’’ – the two terms are largely congruent – will not be possible without a steady stream of creative innovations based on advanced science and technologies, among which biotechnology is likely to play an increasing role.

C. Although definitions of sustainable development have frequently proved elusive, it is clear that any move towards industrial sustainability will affect all stages of a product’s or process’s life cycle. It will require new design principles based on a global and holistic approach to reducing environmental impacts: global because these impacts transcend national borders, holistic because short-term, piecemeal solutions to address a succession of issues in isolation will be less and less effective. One important means of integrating environmental issues into industrial design and operations is the adoption of Life Cycle Assessment (LCA).

D. There are three main drivers of clean technology:
(a) Economic competitiveness, with companies considering the advantages of clean products and processes in terms of market niches or cost advantages;
(b) Government policies, which enforce or encourage changes in manufacturing practices; and
(c) Public pressure, which takes on strategic importance as companies seek to establish environmental legitimacy.

E. It is possible to foresee a growing role for industrial process biotechnology, both because it may afford clear economic and environmental benefits, and because the power of the tool itself continues to grow. The expectations of greater cleanliness come from the observation that living systems manage their chemistry rather more efficiently than man-made chemical plants, and that their wastes tend to be recyclable and biodegradable. This, along with our increasing ability to manipulate biological materials and processes, strongly points to a significant impact on the future of manufacturing industries.

F. Here there is a brief picture of how modern process biotechnology is penetrating industrial operations:

(i) Biotechnology embraces a wide range of techniques, and none of these will apply across all industrial sectors. Nonetheless, the technology is so versatile that many industries that have not used biological sciences in the past are now exploring the possibility of doing so. Already, the economic competitiveness of a variety of biotechnological applications to achieve cleanliness has been established. This is essential, as environmental benefits alone have seldom driven the adoption of biotechnology-based processes. Such processes have been successfully integrated into some large-scale operations. However, a number of problems remain for industrial applications, particularly the entrenched infrastructure of companies that have traditionally relied on physical and chemical technology alone and whose engineers have no training in life sciences or technologies.

(ii) Chemicals manufacturing is a major generator of materials, a major consumer of energy and non-renewable resources, and a major contributor to waste and pollution. In these sub-sectors, market penetration of biotechnology varies. It is in the fine chemical industries that the impact of clean biotechnology is most visible.

(iii)While fossil carbon (oil, coal) is the single most important raw material for energy generation and for chemicals, the concomitant CO2 emissions are a source of increasing concern because CO2 is a major greenhouse gas. Biotechnology can contribute to reducing fossil carbon consumption and hence global warming in various ways: improving industrial processes and energy efficiency, and producing biomass-based materials and clean fuels.

(iv) In pulp and paper, market penetration of biotechnology used for clean production is particularly high in many of the developed nations, and biotechnology is becoming more important in the manufacture of textiles and leather throughout the western world.

(v) In the food and feed sector, the impact of biotechnology on clean industrial processes seems to be greatest in the United States.

(vi) Biotechnology for mining and metals recovery covers two major technologies: bioleaching/minerals bio-oxidation, where superior cleanliness and economic profitability have been claimed in specific cases, and metals bioremediation and recovery.

(vii) In the energy sector, biotechnology has had a major effect both on economics and on environmental impacts. It has improved the overall efficiency of processes, particularly in the area of pollution control. Processes currently under development, such as bio-diesel, bio-ethanol and bio-desulphurisation, seek to replace energy-intensive and polluting systems with systems that are more environmentally friendly. The effect of rDNA methods on these technologies will be great, but large-scale application of rDNA has only recently begun and has not yet had dramatic effects.

G. Although the potential of biotechnology to reduce raw materials and energy consumption as well as wastes is attractive, there is a need for further encouragement, notably by government, particularly when the economic advantages are not overwhelming in the early stages of adoption.

Bio-Ethanol is a renewable fuel to be blended with gasoline:

Bio-Ethanol is a renewable fuel to be blended with gasoline:

Ethanol or alcohol can be used as fuel very effectively, as a bio-fuel alternative to gasoline. In many of the countries it is used in running vehicles. As it is easier to manufacture and process, it is steadily becoming a promising alternative to gasoline almost throughout the world. It is mainly processed from sugar cane – a very common agricultural produce. Anhydrous ethanol, i.e., ethanol having less than 1% of water, can be blended very effectively with gasoline in varying proportion. 10% ethanol blended gasoline is common in most of the countries for running motor vehicles.

Current interest in ethanol mainly lies in ‘bio-ethanol’ that is produced from agricultural based starch or sugar. Basically, carbon-based feedstocks are used for bio-ethanol production. Agricultural feedstocks are considered renewable. Feedstock such as sugar cane, bagasse, miscanthus, sugar beet, sorghum, grain sorghum, switch-grass, barley, hemp, kenaf, potatoes, sweet potatoes, cassava, sunflower, fruit, molasses, corn, stover, grain, wheat, straw, cotton and other biomass can be used for production of bio-ethanol.

The basic steps for large scale production of bio-ethanol are: (a) microbial (yeast), i.e., fermentation of sugars; (b) distillation; (c) dehydration and (d) denaturing.

There has been considerable debate about actual usefulness of bio-fuel like bio-ethanol. Replacing fossil fuels by bio-ethanol take large area of arable land mass, which would have been cultivated for food crops. Moreover, the energy and pollution balance of the whole cycle of ethanol production is also not known.